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Volume 42, Issue 5, May 2026
Original Paper
Sequence analysis
BABAPPAlign: a multiple sequence alignment engine with a learned residue-level scoring function
Bioinformatics, Volume 42, Issue 5, May 2026, btag189, https://doi.org/10.1093/bioinformatics/btag189
MegaPX: fast and space-efficient peptide assignment method using IBF-based multi-indexing
Bioinformatics, Volume 42, Issue 5, May 2026, btag134, https://doi.org/10.1093/bioinformatics/btag134
Genome analysis
MS-ConTab: multi-scale contrastive learning of mutation signatures for Pan-Cancer representation and stratification
Bioinformatics, Volume 42, Issue 5, May 2026, btag131, https://doi.org/10.1093/bioinformatics/btag131
Accelerated long-read variant calling with Clair3 for whole-genome sequencing
Bioinformatics, Volume 42, Issue 5, May 2026, btag181, https://doi.org/10.1093/bioinformatics/btag181
Diagnosing scientific replicability through probabilistic distinguishability
Bioinformatics, Volume 42, Issue 5, May 2026, btag140, https://doi.org/10.1093/bioinformatics/btag140
A framework to infer de novo exonic variants when parental genotypes are missing enhances association studies of autism
Bioinformatics, Volume 42, Issue 5, May 2026, btag177, https://doi.org/10.1093/bioinformatics/btag177
Data and Text Mining
MZSGO: multimodal zero-shot protein function annotation via evolutionary signals and textual semantics
Bioinformatics, Volume 42, Issue 5, May 2026, btag168, https://doi.org/10.1093/bioinformatics/btag168
Metappuccino: large language model-driven reconstruction of sequence read archive metadata for cancer research
Bioinformatics, Volume 42, Issue 5, May 2026, btag166, https://doi.org/10.1093/bioinformatics/btag166
A large-scale neutral comparison study of survival models on low-dimensional data
Bioinformatics, Volume 42, Issue 5, May 2026, btag186, https://doi.org/10.1093/bioinformatics/btag186
Bioimage informatics
Bidirectional Mamba-2 boosts EEG super-resolution via regression and diffusion
Bioinformatics, Volume 42, Issue 5, May 2026, btag169, https://doi.org/10.1093/bioinformatics/btag169
Structural bioinformatics
Molecular fingerprints are strong models for peptide function prediction
Bioinformatics, Volume 42, Issue 5, May 2026, btag179, https://doi.org/10.1093/bioinformatics/btag179
From atoms to fragments: a coarse representation for efficient and functional protein design
Bioinformatics, Volume 42, Issue 5, May 2026, btag172, https://doi.org/10.1093/bioinformatics/btag172
HybridMolGen: a unified framework for goal-directed molecular generation via multi-objective reinforcement learning
Bioinformatics, Volume 42, Issue 5, May 2026, btag170, https://doi.org/10.1093/bioinformatics/btag170
Gene expression
Local transcriptional covariation produces accurate estimates of cell phenotype
Bioinformatics, Volume 42, Issue 5, May 2026, btag135, https://doi.org/10.1093/bioinformatics/btag135
Applications Notes
Genome analysis
CpGene: a web application for epigenetic signature identification from DNA methylation arrays
Bioinformatics, Volume 42, Issue 5, May 2026, btag141, https://doi.org/10.1093/bioinformatics/btag141
nf-core/viralmetagenome: A novel pipeline for untargeted viral genome reconstruction
Bioinformatics, Volume 42, Issue 5, May 2026, btag187, https://doi.org/10.1093/bioinformatics/btag187
Systems biology
HySimODE: a hybrid stochastic-deterministic simulation framework for multiscale models of biological systems
Bioinformatics, Volume 42, Issue 5, May 2026, btag185, https://doi.org/10.1093/bioinformatics/btag185
Genetics and population analysis
NCBoost v2: a classifier for non-coding single-nucleotide variants in Mendelian diseases
Bioinformatics, Volume 42, Issue 5, May 2026, btag138, https://doi.org/10.1093/bioinformatics/btag138
